Pharmaceuticals
August 12, 2021
Gniewko Więckiewicz, Iga Stokłosa, Magdalena Piegza et al.
30 citations
Depression remains a clinical challenge despite many available treatments. Recently, formerly illicit substances such as lysergic acid diethylamide (LSD), psilocybin, and dimethyltryptamine (DMT) have drawn scientific interest. This systematic review followed PRISMA guidelines and searched PubMed and the Cochrane Library, identifying 10 relevant papers. Most selected studies showed a significant correlation between psilocybin and DMT use and reduction in depression symptom intensity. The authors conclude that psilocybin and DMT could be useful in depression treatment, but further observations are still required.
International Journal of Environmental Research and Public Health
January 19, 2023
Iga Stokłosa, Gniewko Więckiewicz, Maciej Stokłosa et al.
25 citations
No single effective drug for alcohol abuse has been identified, despite centuries of effort, due to the complexity of alcohol dependence. Psychotherapy remains the main treatment, with few FDA-approved medications—acamprosate, disulfiram, and naltrexone—and nalmefene approved by the EMA available to augment it. Recent reports suggest baclofen, topiramate, varenicline, and gabapentin may be useful. Clinical trials with psilocybin and MDMA show promise as breakthroughs, but much more research is needed before new pharmacological treatments become widely available.
Medicina
May 9, 2023
Gniewko Więckiewicz, Julia Marek, Iga Stokłosa et al.
5 citations
A large Polish survey of 1,117 drug users found that marijuana, MDMA, and hallucinogenic mushrooms are the most commonly used substances, while amphetamine use is the most common reason for seeking medical help. Over 41 percent of respondents were receiving psychiatric treatment, with depressive disorders, anxiety disorders, and ADHD being the most frequent diagnoses. Compared to two years earlier, psilocybin and DMT use increased, heated tobacco product use rose, and the percentage receiving psychiatric help nearly doubled.