Positive expectations predict improved mental-health outcomes linked to psychedelic microdosing
Scientific Reports January 21, 2021 Laura Kaertner, Michael B. Steinborn, Hannes Kettner et al. 152 citations
A prospective study of weekly psychedelic microdosing found that participants reported improved well-being, emotional stability, and reduced anxiety and depressive symptoms over four weeks. However, baseline positive expectancy scores predicted these improvements, suggesting a significant placebo response. The findings caution against overinterpreting the therapeutic value of microdosing.