The Neurocircuitry of Substance Use Disorder, Treatment, and Change: A Resource for Clinical Psychiatrists
American Journal of Psychiatry October 9, 2024 Caesar G. Imperio, Frances R. Levin, Diana Martínez 9 citations
Substance use disorder is common among psychiatric patients and often goes untreated, negatively affecting health. This review provides a neuroscience-based framework for psychiatrists to address SUD. It describes how pharmacotherapy can target craving, intoxication, and withdrawal to interrupt the substance use cycle. The neuroscience of stress is reviewed, including medications that act on neurotransmitter systems involved in alarm and fear. Treatments that promote neuroplasticity, such as ketamine, psilocybin, and transcranial magnetic stimulation, are discussed. The review concludes with resources and practice guidelines for physicians.