Gymnopilin K: a new cytotoxic gymnopilin from Gymnopilus spectabilis
The Journal of Antibiotics December 21, 2011 Ki Hyun Kim, Sang Un Choi, Kang Ro Lee 22 citations
A new compound, gymnopilin K, along with four known compounds, was isolated from the hallucinogenic mushroom Gymnopilus spectabilis, collected in Korea. The chloroform-soluble fraction of the mushroom extract showed significant cytotoxicity against A549, SK-OV-3, SK-MEL-2, and HCT-15 human tumor cell lines in a sulforhodamine B bioassay. The structure of gymnopilin K was determined using NMR spectroscopy and chemical reactions. This work describes the isolation and structural elucidation of these compounds and reports their cytotoxic activities.