Psychedelic Drugs in Mental Disorders: Current Clinical Scope and Deep Learning‐Based Advanced Perspectives
Advanced Science March 20, 2025 Sung‐hyun Kim, Sumin Yang, Jeehye Jung et al. 5 citations
Psychedelic drugs such as psilocybin and LSD show renewed potential for treating mental disorders like anxiety, major depressive disorder, and autism spectrum disorder. However, individual genetic, epigenetic, and neural circuit differences create complex pharmacological responses, making precise prescription challenging. This review examines recent studies on psychedelics' diverse effects, covering structural function, the microbiota-gut-brain axis, and transcriptome perspectives. It also highlights deep learning and big data approaches as promising tools to clarify mechanisms and interindividual factors, aiming to improve drug discovery and advance precision medicine for psychiatric conditions.