PM504. Theory of Mind in Clinical high risk as trait marker of conversion to psychosis: review
The International Journal of Neuropsychopharmacology May 27, 2016 Jee-Hyung Suh, Tae Young Lee, Jun Soo Kwon 1 citation
Psilocybin, a hallucinogen that mimics psychotic symptoms, alters brain connectivity in ways similar to psychosis. In a double-blind placebo-controlled trial with 20 healthy subjects, standard coherence analysis showed decreased connectivity in theta, alpha, and beta brainwave bands, particularly in frontotemporal and frontoparietal regions, along with frontal interhemispheric disconnection. Changes in higher frequencies were less significant and often opposite. In contrast, eLORETA connectivity analysis found no changes in lower frequencies but increased connectivity in high gamma (50-100 Hz). These preliminary results suggest psilocybin-induced connectivity changes align with those seen in psychotic patients.