Psilocybin-assisted therapy and depression - a systematic review
Open Repository of the University of Porto (University of Porto) June 5, 2020 Rui Pedro Leal Andrade
A review of four clinical trials found that psilocybin-assisted therapy produced immediate and substantial improvements in depression that could last up to six months. Two of the trials involved 32 patients with treatment-resistant depression; the other two involved 80 patients with cancer-related anxiety and depression. The authors note that the small sample sizes mean future studies are needed to confirm the positive association and to fully understand psilocybin's mechanisms and effects.