Psilocybin: Systematic review of its use in the treatment of depression
European Psychiatry April 1, 2025 P. Andres-Olivera, Janis V. de la Iglesia, E. Dominguez-Alvarez et al.
Psilocybin, a psychedelic compound, shows promise for treating depression, particularly when standard treatments fail. This systematic review of studies published between 2019 and 2024 found that psilocybin leads to significant improvements in depressive symptoms compared to conventional therapies, with rapid and sustained symptom reduction and few adverse effects. The review concludes that psilocybin may be an effective and safe alternative, offering relief with fewer treatment sessions and a favorable safety profile, though more research is needed to understand its mechanisms and address current limitations.