Psilocybin alleviates high-glucose and high-lipid-induced skin aging in BJ5Ta fibroblasts
Biochemistry and Cell Biology January 1, 2025 Farzaneh Norouzkhani, Esmaeel Ghasemi Gojani, Bo Wang et al. 1 citation
A high-glucose and high-lipid diet accelerates cellular aging through oxidative stress, mitochondrial dysfunction, and inflammation, contributing to collagen degradation and skin aging. Psilocybin, a naturally occurring compound, was tested on BJ-5ta fibroblasts exposed to such conditions. Post-treatment with 15 µmol/L psilocybin and co-treatment with 10 µmol/L preserved cell viability and reduced senescence markers. The 10 µmol/L co-treatment most effectively lowered apoptosis and alleviated cell cycle arrest in S phase. Psilocybin also decreased inflammatory cytokines IL-1β, IL-6, and COX-2, and co-treatment significantly upregulated elastin gene expression, though fibroblast migration increased nonsignificantly. Psilocybin shows promise as a natural compound for reducing skin aging under oxidative stress.