Hormonal Influences on Psilocybin Responsivity Across the Female Lifespan: Toward Personalized Psychedelic-Assisted Therapy
Psychoactives November 2, 2025 Faith Ekoh, Shanice Rerrie, James Angud et al. 2 citations
Psilocybin shows therapeutic promise for mood, cognitive, and affective disorders, which are regulated by the serotonergic system. Sex hormones such as estrogen and testosterone can influence serotonin physiology, and females have a higher prevalence of affective disorders and may respond differently to drug therapy. A review of current literature discusses how fluctuating hormonal states across female reproductive phases could affect serotonin dynamics, synaptic plasticity, and the optimal timing of psilocybin treatment. The authors suggest that future research should examine sex hormone influences on psychedelic-assisted therapy to personalize treatment plans.