Clinical treatment of cluster headache with the serotonergic indoleamine psychedelics psilocybin and LSD and with ketamine: A case series
Cephalalgia Reports May 1, 2025 Jonathan A. Leighton, Chieh Grace Lau, Aisha Savdo et al. 2 citations
For people with cluster headache—a severe condition that often resists standard treatments—serotonergic psychedelics such as psilocybin and LSD can prevent attacks. In a case series of nine patients whose cluster headaches had not responded to conventional therapies, all patients improved with at least one treatment (psilocybin, LSD, or ketamine). Eight of the nine responded positively to the psychedelic indoleamines, several experiencing extended attack-free periods. These exploratory clinical data add to existing evidence that these substances are useful for cluster headache and support lowering legal and regulatory barriers to medical access.