Among older U.S. men, those who reported lifetime use of classic psychedelics alone had more than two and a half times the odds of a prostate cancer diagnosis compared with non-users, after adjusting for demographic, behavioral, and clinical factors. In men aged 65 or older, the odds were more than three and a half times higher. The analysis used nationally representative survey data from 2015–2019, covering 19,460 men aged 50 and older. Cannabis-only use and co-use of cannabis and psychedelics did not show a significant association. The authors suggest further research is needed to understand possible reasons and biological mechanisms behind this link.
Among a large US-representative sample of adults, 14% reported lifetime use of classic psychedelics (LSD, psilocybin, mescaline, or peyote). Use was lowest among those with a past cancer diagnosis (12.3%) compared to those recently diagnosed (14.0%) or with no cancer history (14.1%). Each psychedelic was used more often by recently diagnosed than past-diagnosed adults. Among 18-to-34-year-olds, recent cancer patients had about 3.5 times higher odds of peyote use than those without cancer. In adults aged 50 or older, past cancer diagnosis was linked to 21% lower odds of peyote use. The findings suggest patterns of psychedelic use differ by cancer history and age, though the study cannot determine whether use preceded or followed diagnosis.