Psilocybin-assisted psychotherapy in adults with depression – A literature review
Progress in Neuro-Psychopharmacology and Biological Psychiatry September 24, 2025 Marie Celine Dorczok, Gloria Mittmann, Thomas Ettl et al. 2 citations
Psilocybin-assisted therapy combined with structured psychological support produces sustained reductions in depressive symptoms in people with treatment-resistant depression and major depressive disorder. Higher doses generally yield stronger benefits. Despite its potential as a holistic treatment, methodological limitations—including variation in study designs, inconsistent psychological support, and difficulty with blinding due to the drug's subjective effects—underscore the need for standardized protocols in future research to ensure reliable outcomes. Further work is needed to clarify the mechanisms behind its therapeutic effects.