519. PSILOCYBIN ASSISTED PSYCHOTHERAPY FOR OBSESSIVE COMPULSIVE DISORDER, BODY DYSMORPHIC DISORDER, AND ANOREXIA NERVOSA: STUDY PROTOCOL
The International Journal of Neuropsychopharmacology August 1, 2025 N Acevdo, David Castle, Susan L. Rossell
Obsessive compulsive disorder, body dysmorphic disorder, and anorexia nervosa share overlapping cognitive-behavioral and neurobiological features, yet conventional treatments often yield suboptimal outcomes. Psilocybin-assisted psychotherapy shows transdiagnostic potential by improving insight, emotional regulation, and well-being. This paper presents a protocol for an open-label basket trial testing psilocybin-assisted psychotherapy across these three conditions. The protocol was developed from scoping reviews, an international Delphi study on best practices, and qualitative interviews with patients. It uses a transdiagnostic, non-directive approach, includes a psychoeducation booklet and video, a treatment manual for clinicians, clinician- and patient-reported outcomes, opt-in additional support, and long-term follow-up.