Psilocibina en cuidados paliativos: revisión sistemática de los efectos a nivel emocional y espiritual-existenciales
Revista Metropolitana de Ciencias Aplicadas December 21, 2025 Graciela Estefanía Toalombo-Eugenio, Katheryne Viviana Carrillo-Zavala, Verónica Giovanna Mayorga-Núñez
A single psilocybin session with psychotherapeutic support produces rapid, significant, and sustained reductions in anxiety and depression lasting up to six months in palliative care patients. Increases were observed in meaning in life, acceptance, spiritual well-being, and quality of life, along with impactful mystical experiences. One cohort maintained benefits for up to four years, suggesting durable effects on coping and existential perception. Safety outcomes were favorable, with mild and transient adverse events including nausea, in-session anxiety, headache, and temporary physiological increases without serious complications. The evidence indicates that psilocybin administered in a structured clinical setting constitutes a viable option for addressing spiritual needs in palliative care.