Long-lasting alterations in 5-HT2A receptor after a binge regimen of methamphetamine in mice
The International Journal of Neuropsychopharmacology April 24, 2014 Hong‐yi Chiu, Ming‐huan Chan, Mei-Yi Lee et al. 31 citations
A single-day 'binge' dosing regimen of methamphetamine in male mice impaired recognition memory, reduced social behaviors, and increased sensitivity to a hallucinogenic drug that activates serotonin 5-HT2A receptors. The heightened behavioral, molecular, and electrophysiological responses to the hallucinogen were linked to an up-regulation of 5-HT2A receptors in the medial prefrontal cortex, while 5-HT2C and 5-HT1A receptors remained unchanged. These findings suggest that methamphetamine-induced changes in 5-HT2A receptor expression may contribute to psychosis-like behaviors and could inform therapies for methamphetamine-related psychiatric disorders.