A systematic review of 40 studies with 6941 participants found a moderate association between developmental trauma (abuse or neglect before age 18) and dissociation in people with psychosis. Sexual and emotional abuse showed the strongest links to dissociation. Dissociation partially explained the connection between developmental trauma and positive psychotic symptoms, especially hallucinations, and also contributed to paranoia and delusional ideas. Individuals with psychosis and developmental trauma reported more dissociation than those without trauma. The review recommends screening for psychotic and dissociative symptoms in trauma survivors and managing dissociation, while calling for more longitudinal, qualitative, and experimental research.
Four patients in Chengdu, China, were poisoned after eating 16–90 g of wild mushrooms misidentified as edible but later confirmed as Psilocybe keralensis. Symptoms began within 5–20 minutes, with hallucinations starting between 10 and 180 minutes. All developed hypertension, one with a rapid rise to 182/110 mmHg and evidence of myocardial injury (peak cardiac troponin T 188.70 pg/mL) and transient skeletal muscle involvement. Supportive treatment led to full recovery. The authors note that altered myocardial biomarkers signal potential cardiovascular risks and recommend cardiac monitoring for high-risk patients in future psilocybin research, and that wild mushroom foraging should be avoided.