Psychedelic-inspired drug discovery using an engineered biosensor.
Cell April 28, 2021 Chunyang Dong, Calvin Ly, Lee E. Dunlap et al. 207 citations
A biosensor engineered from a serotonin 2A receptor can detect psychedelic-like activity in molecules, enabling high-throughput screening for new compounds. The approach identifies structural features that trigger receptor activation, which may accelerate the development of drugs with therapeutic potential and reduced hallucinogenic side effects.