Exploring the first use of psychedelic macrodoses in Latin American adults: Sociodemographic profiles, consumption factors, and subjective experiences
Journal of Psychedelic Studies November 20, 2025 Óscar Véliz‐garcía, Marcos Domic‐siede
Among 4,810 Latin American adults from six countries, the most common first psychedelic macrodose was psilocybin mushrooms (57.6%), followed by LSD (33.3%) and MDMA (17.5%). Most used these substances for recreation (70.5%), with spiritual (21.6%) and therapeutic (5.2%) motivations less frequent. Consumption typically occurred in social settings, especially with friends (65.7%), and 9.1% used them alone. Psilocybin was linked to introspection and well-being, ayahuasca to mystical states, and MDMA to heightened empathy. Familiar environments were associated with more positive experiences. Although 86.3% continued use, the main reason for stopping was lack of opportunity, not negative outcomes.