5-Methoxy-N,N-Dimethyltryptamine: Functional Safety Pharmacology and Video-EEG Assessment of a Short-Acting Serotonergic Psychedelic in Beagle Canines.
International journal of toxicology January 31, 2026 Amir Lotfi, Samantha Sparapani, Mylene Pouliot et al.
5-MeO-DMT, a serotonin receptor agonist being developed for major depression, was tested for seizure risk in beagle dogs. Eight dogs received intranasal doses of 0.5, 1.0, and 1.5 mg/kg/day for nine days. Continuous EEG monitoring showed no seizures or epileptiform discharges at any dose, despite dose-dependent behavioral signs of serotonergic stimulation such as head shaking, tremors, and dilated pupils. These signs correlated with peak plasma levels and resolved within an hour. In a canine model sensitive to serotonergic drug-induced seizures, 5-MeO-DMT did not induce seizures, indicating low seizure liability.