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Jack Freestone

The National Centre for Clinical Research On Emerging Drugs (NCCRED), c/o the University of New South Wales, Randwick, NSW, Australia.

3 papers in the library · 1 citation · publishing 2026

Papers

'A fine line between euphoria and death': a qualitative study exploring gamma-hydroxybutyrate (GHB) use among people who identify as heterosexual living in Australia.

Harm reduction journal February 6, 2026 Keaton Hudson-Buhagiar, Jonathan Brett, Alanah Spillane et al. 1 citation

Among heterosexual Australians who use GHB, three patterns of use—occasional, regular, or daily—emerged. Four key themes were identified: escapism (managing mental health symptoms, enhancing confidence, facilitating sex, and alleviating body consciousness in women); diverse understandings of overdose, including intentional dosing to achieve unconsciousness and misconceptions about using stimulants to counter toxicity, with fear of police delaying help-seeking; stigma from both drug-using and non-using peers; and gendered harm reduction practices where women protect each other from harms, especially sexual violence. Findings point to gaps in public health education on overdose management and intentional risk-taking.

Navigating ‘k-land’: a qualitative exploration of participants’ experiences of ketamine-assisted psychotherapy for methamphetamine use disorder

Frontiers in Psychiatry June 24, 2026 Kathryn Fletcher, Nadine Ezard, Krista J. Siefried et al.

People with methamphetamine use disorder who underwent ketamine-assisted psychotherapy described the treatment as a multi-stage process rather than a simple drug effect. Participants reported that ketamine created a temporary state of reduced emotional and cognitive reactivity, which they called 'psychological space,' making them more receptive to psychotherapy. However, behavioral changes—including reduced methamphetamine use—were variable and depended on ongoing therapeutic engagement, personal motivation, and life context. Participants were uncertain whether improvements came from the ketamine, the therapy, or the supportive environment. Acceptability was generally high when treatment occurred in a structured clinical setting.

Exploring the Utility and Appropriateness of Dose Thresholds for Issuing of Public Drug Alerts on High-Dose MDMA: A Qualitative Study.

Drug and alcohol review March 1, 2026 Jack Freestone, Harriet MacDonald, Stassi Kypri et al.

Drug alerts in Australia are triggered when MDMA pills contain at least 150 mg of free-base MDMA, a threshold experts consider reasonable despite its limitations. Nineteen such alerts were issued in 2024, raising concerns about diminishing impact. Fifteen experts who design and disseminate drug alerts completed a survey, and seven participated in a focus group. Most agreed 150 mg is a reasonable threshold because it enables rapid communication and addresses potential harm, though thresholds cannot account for evolving manufacturing or consumption trends. Limited capacity to monitor community perceptions means there is little evidence to justify changing the threshold. Notifying communities about high-dose MDMA remains a harm-reduction priority; improving monitoring and establishing a dosage database could enhance future risk communication.