Psychedelics for treatment resistant depression: are they game changers?
Expert Opinion on Pharmacotherapy November 10, 2023 Michail Kalfas, Rosie H Taylor, Dimosthenis Tsapekos et al. 28 citations
Psychedelic therapy is transforming treatment for treatment-resistant depression (TRD) by increasing benefits and reducing risks. Psilocybin shows promise as a potential game-changer, with initial evidence indicating a rapid antidepressant effect that lasts at least three months for some responders. However, more rigorous, double-blind, comparator-controlled trials with adequate statistical power are needed to understand how psychedelics work and their long-term effects in TRD. Psychedelics may also benefit other psychiatric conditions like bipolar depression and post-traumatic stress disorder.