The Therapeutic Potential of Psychedelics for Treatment-resistant Depression: Reality or Hallucination? A Systematic Review.
Journal of clinical psychopharmacology January 12, 2026 Natia Horato, Felipe Dalvi-Garcia, Pablo E P Dutra et al. 1 citation
A systematic review of 15 studies (10 randomized double-blind controlled trials and 5 open-label trials) examined the efficacy of psychedelics for treatment-resistant depression (TRD), a severe subtype of major depressive disorder. The review suggests that both typical and atypical psychedelics can provide rapid and substantial improvement in depressive symptoms, representing an alternative and complementary therapeutic approach to traditional treatments for TRD.