The Psychedelic N,N-Dipropyltryptamine Prevents Seizures in a Mouse Model of Fragile X Syndrome via a Mechanism that Appears Independent of Serotonin and Sigma1 Receptors
ACS Pharmacology & Translational Science September 18, 2023 Richa Tyagi, Tanishka S. Saraf, Clinton E. Canal 5 citations
A psychedelic tryptamine, DPT, completely prevented sound-induced seizures in a mouse model of fragile X syndrome at a 10 mg/kg dose but not at lower doses. Although DPT activates several serotonin receptors in the lab, blocking those receptors did not stop its anti-seizure effect, nor did blocking sigma1 receptors. The anti-seizure action appears independent of DPT's psychedelic properties. However, high doses of DPT caused convulsions on their own, indicating complex, dose-dependent effects.