Use of Lysergic Acid Diethylamide by Major Depression Status.
JAMA psychiatry January 1, 2024 Claire A Walsh, Lauren Gorfinkel, Dvora Shmulewitz et al. 24 citations
From 2008 to 2019, past-year LSD use increased more among US adults with major depression (from 0.5% to 1.8%) than among those without depression (from 0.2% to 0.8%), a difference-in-difference of 0.8 percentage points. The increase was especially pronounced in adults aged 18–34 with depression and in those with annual household incomes below $75,000. The findings suggest that growing clinical interest in hallucinogens may be accompanied by rising nonmedical LSD use among people with depression, particularly younger adults and those with lower incomes. Clinicians are advised to discuss harm reduction and potential benefits with patients who use LSD in unsupervised settings.