Journal of affective disorders
February 1, 2023
Kwonmok Ko, Emma I Kopra, Anthony J Cleare et al.
144 citations
A systematic review and meta-analysis of 14 studies (7 randomized controlled trials) examined the effects of classic psychedelics (psilocybin, ayahuasca, LSD) on depressive symptoms. The review found significant reductions in depressive symptoms at 1 day, 1 week, and 3-5 weeks after treatment with psychological support. Results at 6-8 weeks were less conclusive. Small sample sizes in most studies and lack of long-term follow-up data limited statistical power and interpretation. The findings suggest an association between psychedelic therapy and short-term symptom reduction, but more rigorous trials with larger, diverse samples are needed.
Neuropsychiatric disease and treatment
January 1, 2023
Kwonmok Ko, Ben Carter, Anthony J Cleare et al.
26 citations
In psychedelic therapy, both mystical and challenging experiences may affect treatment outcomes, but what predicts their intensity is not well understood. Analyzing data from a randomized, double-blind, placebo-controlled trial, 89 healthy volunteers received a placebo, 10 mg, or 25 mg of psilocybin. Higher dosage strongly predicted greater intensity of both mystical and challenging experiences. Older age was linked to less intense challenging experiences. Personality traits showed little correlation, except that neuroticism correlated with more intense challenging experiences at the higher dose. Positive or negative mood before dosing did not predict experience intensity. The analysis was exploratory and post hoc.
Journal of psychopharmacology (Oxford, England)
January 1, 2025
Gianmarco Ingrosso, Anthony J Cleare, Mario F Juruena
20 citations
A review of 16 studies involving 2,174 patients found that addiction phenomena during ketamine treatment for depression are rare. Only four patients showed clear signs of tolerance or dependence, while the vast majority did not. The review included randomized controlled trials and other study designs using various routes of administration, including intravenous and intranasal esketamine. The findings suggest that medically supervised ketamine treatment is relatively safe for adult depression patients, though the authors emphasize the need for vigilant monitoring and careful dosing. Future research using standardized scales could further strengthen evidence for safe use.
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology
April 1, 2025
Eduard Vieta, Nahida Ahmed, Celso Arango et al.
12 citations
Patients with treatment-resistant depression who received esketamine nasal spray experienced 43.2% more weeks with functional remission over 32 weeks compared to those taking quetiapine extended release, a difference of 2.0 weeks. Esketamine also led to an 11.9% reduction in productivity loss due to absenteeism and a 14.2% reduction in overall work productivity loss. Both treatments were taken alongside an ongoing SSRI or SNRI. The findings suggest that esketamine provides greater improvements in daily functioning and workplace productivity for this patient group.