The effect of psilocin on neurotransmitters release in the claustrum and on rat behavior.
Pharmacological reports : PR February 1, 2026 Zuzanna Kościuk, Izabela Szpręgiel, Agnieszka Bysiek et al. 2 citations
Psilocin and 25I-NBOMe, two serotonergic psychedelics, both altered neurotransmitter levels in the rat claustrum but produced distinct neurochemical profiles. Psilocin elevated noradrenaline and acetylcholine, yielding a balanced excitatory–inhibitory pattern, while 25I-NBOMe induced a stronger excitatory shift with the largest increase in serotonin release. These differences reflect psilocin's engagement of both 5-HT2A and 5-HT1A receptors versus 25I-NBOMe's selective, high-affinity 5-HT2A agonism. The claustrum is highlighted as a convergence point for psychedelic action, and the contrasting profiles suggest fundamentally different therapeutic and toxicological potentials.