Tomáš Hložek

2 papers in the library · 30 citations · publishing 2019-2024

Papers

Cannabis-induced altered states of consciousness are associated with specific dynamic brain connectivity states

Journal of Psychopharmacology June 3, 2019 Yuliya Zaytseva, Jiřı́ Horáček, Jaroslav Hlinka et al. 25 citations

Delta-9-tetrahydrocannabinol, the active compound in cannabis, temporarily alters how brain regions communicate with each other. In 19 occasional cannabis users who underwent two resting-state fMRI scans—one shortly after smoking a cannabis cigarette and one after at least a week without cannabis—a transient connectivity state appeared only during intoxication. This state showed high connectivity within and between auditory and somato-motor cortices, along with anti-correlation with subcortical structures and the cerebellum. Subjective perceptual changes and THC plasma levels were linked to this state, suggesting a neural biomarker of cannabis intoxication.

DOI: 10.1177/0269881119849814 Cannabis Precuneus Delta-9-tetrahydrocannabinol Resting State FMRI +7

Methoxetamine and its metabolites: Postmortem determination in body fluids of human cadaver.

Journal of analytical toxicology January 31, 2024 Miroslava Bursová, Tomáš Hložek, Miloš Sokol et al. 5 citations

A 42-year-old man who used drugs died at home and his body was found two months later. Autopsy did not reveal an obvious cause of death, but toxicology screening using liquid chromatography and mass spectrometry detected methoxetamine (MXE), a ketamine analog, and several of its metabolites in blood, urine, and gastric contents. MXE concentrations were 3.6 ng/mL in blood, 70.5 ng/mL in urine, and 18.0 ng/mL in gastric content. No other drugs or poisons were found, so despite the low blood level, MXE likely contributed to the death. The case shows that MXE and its metabolites can be detected in a decomposing body even after two months.

DOI: 10.1093/jat/bkad084 Full text