Hair-based rapid UPLC-MS/MS analysis of 36 phencyclidine-type substances in forensic cases.
Journal of pharmaceutical and biomedical analysis September 20, 2023 Ziyi Li, Zehong Li, Wanting Xie et al. 13 citations
A method using ultra performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) was developed and validated to detect phencyclidine-type substances in human hair. The method showed good sensitivity, selectivity, and accuracy. It was applied to hair samples from 87 authentic forensic cases, identifying and quantifying nine analytes including ketamine, 2-F-2-oxo-PCE, 2-FDCK, 2-BrDCK, nor2-FDCK, tiletamine, O-PCE, DCK, and norDCK at various concentrations. This approach provides technical support for monitoring abuse of these substances, which are often synthesized as substitutes for controlled drugs.