The high frequency oscillation in orbitofrontal cortex is susceptible to phenethylamine psychedelic 25C-NBOMe in male rats.
Neuropharmacology April 1, 2023 Zhi-Peng Yu, Qiong Li, Zhou-Xiao Wu et al. 7 citations
The substituted phenethylamine psychedelic 25C-NBOMe, at a dose of 0.1 mg/kg that disrupts sensorimotor gating, selectively potentiates high frequency oscillation (HFO, 120-150 Hz) power in the orbitofrontal cortex (OFC) of male Sprague-Dawley rats, peaking 20-30 minutes after treatment. It strengthens HFO coherence within the intra-prefrontal network but not the hippocampal-prefrontal network. Potentiated OFC HFO strongly correlates with strengthened inter-prefrontal HFO coherence. Pre-treatment with the serotonin 2A receptor antagonist MDL100,907 prevents these alterations. The findings indicate that OFC HFO is particularly susceptible to this psychedelic and may drive drug-induced rhythmic coherence within prefrontal regions, suggesting altered HFO could serve as a biological marker of psychedelic effects.