Effect of -NBOMe Compounds on Sensorimotor, Motor, and Prepulse Inhibition Responses in Mice in Comparison With the 2C Analogs and Lysergic Acid Diethylamide: From Preclinical Evidence to Forensic Implication in Driving Under the Influence of Drugs.
Frontiers in psychiatry January 1, 2022 Micaela Tirri, Sabrine Bilel, Raffaella Arfè et al. 17 citations
Psychedelic phenethylamines, especially -NBOMe compounds, impair sensorimotor function, reaction time, and sensory gating in mice more potently than LSD or their 2C analogs. Halogenated derivatives 25I-NBOMe and 25B-NBOMe were the most effective at altering visual and acoustic responses, motor activity, and prepulse inhibition. The rank order of potency showed these -NBOMe compounds were stronger than both 2C analogs and LSD. These sensory impairments affected spontaneous movement and reaction time without changing stimulated motor performance. The findings suggest that -NBOMe compounds pose potential public health risks, particularly for driving or hazardous work requiring intact sensorimotor skills.