Giovanni Serpelloni

Neuroscience Clinical Center and Transcranial Magnetic Stimulation (TMS) Unit, Verona, Italy.

2 papers in the library · 212 citations · publishing 2016-2022

Papers

Neuropharmacology of New Psychoactive Substances (NPS): Focus on the Rewarding and Reinforcing Properties of Cannabimimetics and Amphetamine-Like Stimulants

Frontiers in Neuroscience April 19, 2016 Cristina Miliano, Giovanni Serpelloni, Claudia Rimondo et al. 195 citations

New psychoactive substances (NPS) are a diverse and rapidly expanding group of molecules sold as substitutes for controlled drugs, often consumed with other substances or alcohol, and linked to rising overdose deaths and emergency admissions. Their chemical classes include phenethylamines, piperazines, cathinones, tryptamines, and synthetic cannabinoids, with the latter accounting for 50% of newly identified NPS. Many NPS show addictive properties. This review examines the rewarding and addictive effects of cannabimimetics (JWH, HU, CP series) and amphetamine-like stimulants, including recent lab data showing that JWH-018, a potent CB1/CB2 agonist, increases dopamine signaling in the nucleus accumbens shell, contributing to dependence associated with 'Spice' use.

DOI: 10.3389/fnins.2016.00153 MDMA Addiction Synthetic cannabinoids Neuropharmacology +8

Effect of -NBOMe Compounds on Sensorimotor, Motor, and Prepulse Inhibition Responses in Mice in Comparison With the 2C Analogs and Lysergic Acid Diethylamide: From Preclinical Evidence to Forensic Implication in Driving Under the Influence of Drugs.

Frontiers in psychiatry January 1, 2022 Micaela Tirri, Sabrine Bilel, Raffaella Arfè et al. 17 citations

Psychedelic phenethylamines, especially -NBOMe compounds, impair sensorimotor function, reaction time, and sensory gating in mice more potently than LSD or their 2C analogs. Halogenated derivatives 25I-NBOMe and 25B-NBOMe were the most effective at altering visual and acoustic responses, motor activity, and prepulse inhibition. The rank order of potency showed these -NBOMe compounds were stronger than both 2C analogs and LSD. These sensory impairments affected spontaneous movement and reaction time without changing stimulated motor performance. The findings suggest that -NBOMe compounds pose potential public health risks, particularly for driving or hazardous work requiring intact sensorimotor skills.

DOI: 10.3389/fpsyt.2022.875722 Full text LSD -nbome 2c compounds Phenethylamine +2