Method development for the identification of methoxpropamine, 2-fluoro-deschloroketamine and deschloroketamine and their main metabolites in blood and hair and forensic application.
Forensic science international June 1, 2021 Serena Mestria, Sara Odoardi, Giulia Biosa et al. 30 citations
Three novel ketamine analogues—methoxpropamine, 2-fluoro-deschloroketamine, and deschloroketamine—were identified in post-mortem blood and hair samples from a suicide by fall from height, using liquid chromatography-high resolution mass spectrometry (LC-HRMS). The analysis also detected several of their metabolites. These substances belong to the β-keto-arylcyclohexamine class of new psychoactive substances (NPS), which are often sold as 'research chemicals' and may be consumed unintentionally by buyers unaware of product contents. The work provides analytical methods for detecting these compounds and their metabolites, offering a foundation for studying their toxicokinetics.