Flavio Zancanaro

2 papers in the library · 29 citations · publishing 2008-2020

Papers

Analytical Characterization of 3-MeO-PCP and 3-MMC in Seized Products and Biosamples: The Role of LC-HRAM-Orbitrap-MS and Solid Deposition GC-FTIR.

Frontiers in chemistry January 1, 2020 Giampietro Frison, Flavio Zancanaro, Samuela Frasson et al. 29 citations

Two powders seized by police were identified as the dissociative hallucinogen 3-MeO-PCP and the psychostimulant 3-MMC. Liquid chromatography–high-resolution mass spectrometry (LC-HRAM-Orbitrap-MS) assigned the elemental formulas but could not distinguish between positional isomers of each drug. Solid deposition gas chromatography–Fourier transform infrared spectroscopy (sd-GC-FTIR) unambiguously differentiated the isomers by matching experimental infrared spectra against a library, confirming 3-MeO-PCP and 3-MMC. 3-MeO-PCP was also detected in blood and urine from both subjects, along with dozens of its phase I and phase II metabolites, using LC-HRAM-Orbitrap-MS after deproteinization. sd-GC-FTIR further confirmed 3-MeO-PCP in biological samples. The combined techniques provided full structural characterization without reference standards.

DOI: 10.3389/fchem.2020.618339 Full text 3-methoxyphencyclidine 3-methylmethcathinone Forensic toxicology Gas chromatography +1

A case of beta-carboline alkaloid intoxication following ingestion of Peganum harmala seed extract.

Forensic science international August 6, 2008 Giampietro Frison, Donata Favretto, Flavio Zancanaro et al.

Beta-carboline alkaloids such as harmine, harmaline, and tetrahydroharmine, found in plants like Peganum harmala, Passiflora incarnata, and Banisteriopsis caapi, can stimulate the central nervous system by inhibiting amine neurotransmitter metabolism or directly interacting with receptors. Ingestion of preparations containing these alkaloids can cause toxic effects including hallucinations, ataxia, nausea, vomiting, confusion, and agitation. This report describes a case of intoxication after intentionally drinking an infusion of P. harmala seeds purchased online. The alkaloids were identified in the seed extract and the patient's urine via gas chromatography-mass spectrometry, marking the first confirmed case of P. harmala intoxication with toxicological evidence.

DOI: 10.1016/j.forsciint.2008.05.003 Full text