Zebrafish and Artemia salina in vivo evaluation of the recreational 25C-NBOMe drug demonstrates its high toxicity.
Toxicology reports January 1, 2021 Natalie Álvarez-alarcón, Jhon Jairo Osorio-Méndez, Adis Ayala-Fajardo et al. 26 citations
25C-NBOMe, a synthetic hallucinogen from the NBOMe family, is highly toxic in two animal models: brine shrimp (Artemia salina) and zebrafish embryos. Lethality tests showed high toxicity, and the substance altered swimming and motility patterns in brine shrimp. In zebrafish, it caused abnormal motor responses and developmental defects, suggesting teratogenic potential. These findings correlate with clinically reported side effects in human users, such as motor abnormalities and muscle deterioration. This is the first in vivo report on 25C-NBOMe's toxicological and developmental effects, advancing understanding of its impact on behavior and development.