Potential of High-Resolution Mass Spectrometry for the Detection of Drugs and Metabolites in Hair: Methoxetamine in a Real Forensic Case.
Journal of analytical toxicology February 14, 2022 J M Matey, Adrián López-fernández, Carmen García-ruiz et al. 13 citations
Analyzing hair and other biological samples for drugs like methoxetamine requires highly selective and sensitive methods. Traditional target analysis using gas chromatography-mass spectrometry can be complex and less sensitive. Reanalyzing samples from a former case of a polydrug consumer in Spain, five metabolites of methoxetamine were tentatively detected using liquid chromatography coupled to high-resolution mass spectrometry (LC-HR-MS-MS). This method, combined with simpler pretreatment, allowed faster and more sensitive analysis than the traditional approach, demonstrating its utility for detecting low concentrations of new psychoactive substances.