TOLERANCE AND ACCEPTABILITY OF INTRAVENOUS KETAMINE THERAPY FOR TREATMENT RESISTANT DEPRESSION: A MIXED METHODS ASSESSMENT
Journal of Pakistan Psychiatric Society March 3, 2023 Sawera Mansoor, Khalid Hayat Khan, Manzoor Ahmed Faridi 3 citations
Intravenous ketamine therapy produced a rapid improvement in depression severity among 14 patients with treatment-resistant depression, with significant effects observed one hour and two weeks after the final dose. However, this improvement was not significantly sustained at one month. Patients initially expressed safety concerns, comparing the treatment to general anesthesia, but most became advocates for ketamine therapy after experiencing rapid, transformative effects on severe depressive symptoms. The study used a mixed-methods approach, combining a quasi-experimental design with qualitative interviews.