Serotonin and Lysergic Acid Diethylamide Binding in Rat Brain Membranes: Relationship to Postsynaptic Serotonin Receptors
Molecular Pharmacology May 1, 1976 James P. Bennett, Solomon H. Snyder 509 citations
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James P. Bennett
Johns Hopkins University
2 papers in the library · 675 citations · publishing 1975-1976
Papers
Stereospecific binding ofd-lysergic acid diethylamide (LSD) to brain membranes: Relationship to serotonin receptors
Brain Research September 1, 1975 James P. Bennett, Solomon H. Snyder 166 citations
D-LSD binds to rat brain membranes with high affinity and stereospecificity; the psychotropically inactive L-LSD is 1000 times weaker. 2-bromo-LSD, though psychotropically inactive, displaces D-LSD as potently as D-LSD. Serotonin is the only neurotransmitter with affinity for the LSD binding site. Destroying presynaptic serotonin neurons does not alter LSD binding, suggesting the binding site is post-synaptic. Regional distribution in monkey brain shows LSD binding correlates partly with serotonin uptake, but cortical areas are highest in binding and only intermediate in uptake.