Discovery and In Vitro Characterization of SPL028: Deuterated N,N-Dimethyltryptamine.
ACS medicinal chemistry letters September 14, 2023 Marie Layzell, Peter Rands, Meghan Good et al. 6 citations
A deuterated analogue of DMT, called D2-DMT, has a longer half-life and slower clearance in liver cell fractions than standard DMT while maintaining a similar receptor binding profile, making it a promising candidate for extended treatment of major depressive disorder.