Evidence for a central 5‐hydroxytryptamine receptor stimulation by lysergic acid diethylamide
British Journal of Pharmacology September 1, 1968 N.‐e. Andén, H. Corrodi, Kjell Fuxé et al. 274 citations
Lysergic acid diethylamide (LSD) produces functional effects in rat spinal cord and brain similar to those of the serotonin (5-hydroxytryptamine) precursor 5-hydroxytryptophan, indicating that LSD stimulates central serotonin receptors. Using histochemical and biochemical techniques, LSD reduced the turnover rate of serotonin in the brain and spinal cord after inhibition of tryptophan hydroxylase. The turnover of noradrenaline, but not dopamine, was somewhat accelerated. These effects were dose- and time-dependent and were not observed with the LSD analogues 2-bromo-LSD and methysergide. The retardation of serotonin turnover by LSD may result from negative feedback mechanisms triggered by direct stimulation of central serotonin receptors.