Lysergic acid diethylamide and 2,5-dimethoxy-4-methylamphetamine are partial agonists at serotonin receptors linked to phosphoinositide hydrolysis.
Journal of Pharmacology and Experimental Therapeutics September 1, 1988 Elaine Sanders‐bush, Kevin D. Burris, Karen M. Knoth 155 citations
The hallucinogens DOM and LSD act as partial agonists at serotonin 5-HT-2 receptors in rat cerebral cortex and at 5-HT-1c receptors in rat choroid plexus, stimulating phosphoinositide hydrolysis. In cortex, DOM and LSD produced maximum responses 76% and 25% of serotonin's maximum, respectively, with LSD 500 times more potent than DOM. LSD partially blocked serotonin's effect, consistent with partial agonism. In choroid plexus, DOM and LSD reached 67% and 34% of serotonin's maximum, with LSD 50 times more potent than DOM. These effects were blocked by specific serotonin antagonists, supporting the role of 5-HT-2 and 5-HT-1c receptors in mediating hallucinogenic actions.