LSD and 9,10‐dihydro‐LSD Analyses in Street Drug Blotter Samples via Easy Ambient Sonic‐Spray Ionization MassSpectrometry (EASI‐MS)
Journal of Forensic Sciences August 6, 2012 Wanderson Romão, Bruno Duarte Sabino, Maria Izabel M. S. Bueno et al. 24 citations
Forensic identification of LSD typically relies on the Ehrlich spot test, which is nonspecific and cannot distinguish LSD from the uncontrolled substance 9,10-dihydro-LSD, recently found in Brazilian blotters. This work used easy ambient sonic-spray ionization mass spectrometry (EASI-MS) to characterize LSD and 9,10-dihydro-LSD directly from blotter surfaces. Of 41 blotters analyzed by EASI-MS, 28 tested positive for LSD, seven for 9,10-dihydro-LSD, and six for neither. Results were confirmed by high-performance liquid chromatography. Combining thin-layer chromatography with EASI-MS proved a simple, powerful screening tool for forensic drug analysis.