Sertindole and several antipsychotic drugs differentially inhibit the discriminative stimulus effects of amphetamine, LSD and St 587 in rats
Behavioural Pharmacology February 1, 1992 J. Arnt 27 citations
Sertindole, an atypical antipsychotic, blocks the effects of the hallucinogen d-LSD and the alpha-1 agonist St 587 but does not block the effects of d-amphetamine, a dopamine stimulant. Clozapine, another atypical antipsychotic, broadly blocks d-LSD, St 587, and d-amphetamine, though it increases reaction time. The typical antipsychotics haloperidol and Cis(Z)-flupentixol primarily block d-amphetamine, with haloperidol also disrupting behavior in animals trained on St 587 and d-LSD. The selective 5-HT2 antagonist ketanserin blocks only d-LSD, while the alpha-1 antagonist prazosin partially blocks St 587 but not d-LSD or d-amphetamine. Drug discrimination techniques reveal different activity profiles of typical and atypical neuroleptics.