Behavioral sensitivity to LSD: Dependency upon the pattern of central 5HT depletion
Pharmacology Biochemistry and Behavior May 1, 1977 James A. Joseph, James B. Appel 18 citations
Two experiments using a fixed ratio schedule of water reinforcement tested whether serotonin-depleting agents alter sensitivity to a low dose of LSD (0.02 mg/kg). Both p-chloroamphetamine (PCA) and 5,7-dihydroxytryptamine (5,7-DHT) reduced whole-brain serotonin, but only 5,7-DHT increased sensitivity to LSD, disrupting bar-press behavior 12 days after administration. PCA did not produce this effect. However, four PCA-treated animals that showed no increased sensitivity did exhibit behavioral disruption to LSD when pretreated with p-chlorophenylalanine. The pattern of serotonin depletion required for LSD sensitivity may be specific.