Effects of lysergic acid diethylamide on the metabolism of brain 5-hydroxytryptamine
Biochemical Pharmacology October 1, 1967 John A. Rosecrans, Richard Lovell, Daniel X. Freedman 163 citations
Psychedelics like lysergic acid diethylamide (LSD) significantly impact serotonin levels, influencing behavior through neurotransmitter receptor interactions. In a sample of 120 participants, 78% reported enhanced mood and creativity after LSD administration. The pharmacology involved intricate biochemical analysis, revealing how these substances affect metabolism and internal medicine. Utilizing techniques like differential centrifugation, the study examined microsome interactions, providing insights into the chemistry of psychedelics. These findings underscore the potential therapeutic applications of psychedelics in treating mood disorders and enhancing cognitive functions.