Quantification of LSD in illicit samples by high performance liquid chromatography
Brazilian Journal of Pharmaceutical Sciences December 1, 2010 Pablo Alves Marinho, Edna Maria Alvarez Leite 13 citations
A method using high performance liquid chromatography to quantify LSD in blotter papers seized in Minas Gerais was optimized and validated. The method showed linearity between 0.05 and 20.00 μg/mL, with satisfactory precision (intra-assay relative standard deviation 4.4%, inter-assay 6.4%) and mean recoveries of 83.4% and 84.9% at two concentration levels. Detection and quantification limits were 0.01 and 0.05 μg/mL, respectively. Analysis of 22 seized blotters found a mean of 67.55 μg of LSD per blotter (relative standard deviation 27.5%). The method demonstrated satisfactory analytical performance and is suitable for determining LSD in illicit samples.