Characterisation of [3H]lysergic acid diethylamide binding to a 5-hydroxytryptamine receptor on human platelet membranes
European Journal of Pharmacology January 1, 1984 David P. Geaney, Michael Schächter, Jonathan Elliot et al. 90 citations
Tritiated LSD binds specifically and saturably to human platelet membranes, with binding characteristics consistent with a serotonin (5-HT) receptor. The binding affinity is 0.53 nM and capacity is 57.1 fmol/mg protein in control subjects. Inhibition of LSD binding correlates with inhibition of serotonin-induced platelet shape change but not with serotonin uptake. Binding to platelet membranes also correlates with binding to human frontal cortex membranes, suggesting platelets may serve as a peripheral model for studying central serotonin receptors.