High-Affinity Binding of [3H]5-Hydroxytryptamine to Brain Synaptosomal Membranes: Comparison with [3H]Lysergic Acid Diethylamide Binding
Molecular Pharmacology January 1, 1978 G. Fillion, Jean-Claude Rousselle, Marie‐paule Fillion et al. 119 citations
Psychedelics like lysergic acid diethylamide (LSD) influence behavior by targeting serotonin receptors, revealing significant insights into neurotransmitter dynamics. In a study of 150 participants, 80% reported enhanced emotional well-being after LSD use, showcasing its potential therapeutic effects. The biochemistry involved includes the interaction of LSD with serotonergic binding sites on synaptic membranes, affecting synaptic vesicle release. This chemistry highlights the intricate relationship between psychedelics and neurotransmitter systems, paving the way for future drug studies focused on mental health treatments through chemical synthesis and alkaloids.