A case report describes a person who used LSD continuously for two years as his primary drug, developing craving and tolerance that did not disappear rapidly upon discontinuation, contrary to typical understanding. The individual experienced both physical and psychological symptoms when stopping LSD, factors that contributed to continued use. The authors state this is the first report of physical dependence to LSD, as the literature has previously indicated that LSD causes only psychological dependence and that continuous use is unknown.
Transitioning from methadone to buprenorphine for opioid agonist treatment can be limited by factors like withdrawal symptoms and lengthy tapering. A novel approach called microdosing, or the Bernese method, offers a faster alternative. Two cases are described in which patients successfully switched from methadone to buprenorphine using this method, suggesting it may be a valuable option for those who cannot tolerate the classical gradual taper.