Psychopharmacology
January 14, 2020
Débora González, Jordi Cantillo, Irene Hidalgo Pérez et al.
73 citations
In a bereaved sample attending Shipibo ayahuasca ceremonies in Peru, grief severity decreased substantially from baseline to 12 months, with large effect sizes (Cohen's d = 0.84 at 15 days, 1.38 at 3 months, 1.16 at 6 months, and 1.39 at 12 months). Reductions in grief were linked to lower experiential avoidance (r = 0.55) and greater decentering (r = -0.47). The ceremonial use of ayahuasca appears to have therapeutic value for grief, with acceptance and decentering as mediating psychological processes.
OMEGA - Journal of Death and Dying
May 30, 2017
Débora González, Maria Carmo Carvalho, Jordi Cantillo et al.
43 citations
People who took ayahuasca reported lower levels of grief compared to those who attended peer-support groups, as measured by the Present Feelings Scale of the Texas Revised Inventory of Grief. The ayahuasca group showed benefits in psychological and interpersonal dimensions. Qualitative responses described emotional release, biographical memories, and experiences of contact with the deceased. Some benefits were identified regarding the ayahuasca experiences. These results provide preliminary data about the potential of ayahuasca as a therapeutic tool for grief.
Frontiers in Pharmacology
May 5, 2021
Débora González, Jordi Cantillo, Irene Hidalgo Pérez et al.
39 citations
People who took part in an Indigenous Shipibo healing program involving ayahuasca ceremonies showed significant increases in psychological well-being, happiness, and quality of life that lasted up to 12 months. A subgroup analysis indicated the improvements were due to the program rather than the passage of time. A relationship was found between decentering—the ability to observe thoughts and feelings objectively—and enhanced psychological well-being.
Frontiers in Psychology
May 3, 2022
Débora González, Marc Aixalà, Robert A. Neimeyer et al.
15 citations
A woman suffering from complicated grief after her mother's suicide participated in an ayahuasca ceremony followed by Restorative Retelling sessions to process the psychedelic experience. The case report describes how ayahuasca evoked key psychological content related to her loss, and how the adapted Restorative Retelling technique helped integrate that content into autobiographical memory, fostering meaning-making. Evaluations before the ayahuasca experience and after Restorative Retelling suggest reductions in symptoms of complicated grief and general psychopathology. The authors propose that Restorative Retelling can effectively process and integrate psychedelic experiences, though they note limitations of a single case.
Psychedelics
April 20, 2026
José Carlos Bouso, Óscar Andión, Jordi Cantillo et al.
A 12-month study of 264 Western participants who attended Shipibo-led ayahuasca retreats in the Peruvian Amazon found lasting psychological improvements. Neuroticism and Openness to Experience decreased, while Extraversion increased. Quality of life improved across all measured domains, and decentering capacities increased with moderate to high effect sizes. Most participants (91.7%) reported long-term benefits, primarily in spiritual well-being, mental health, and personal growth. Adverse effects were minimal (2.3%). Higher baseline psychological distress was associated with higher Neuroticism and lower decentering, suggesting that enhancing decentering may serve as a resilience factor. The findings support ethical, non-extractive integration of traditional Amazonian practices into global mental health frameworks.
Archives of Pharmacology and Therapeutics
January 1, 2024
Débora González, Jordi Cantillo, José Carlos Bouso
Grief is a universal and recurrent experience, as each of the approximately 58 million annual deaths worldwide directly affects about nine close relatives. This underscores that bereavement is not a one-time event but a process that can occur multiple times across a person's life.